ABSTRACT
Objective:To study the clinical efficacy of acupuncture at Zusanli (ST 36)combined with Traditional Chinese Medicine (TCM) enema in the treatment of gastroparesis syndrome after gastrointestinal tumor operation.Methods:A total of 96 patients with gastroparesis syndrome after gastrointestinal tumor surgery in our hospital from June 2016 to May 2021, who met the inclusion criteria, were randomly divided into three groups by random drawing, with 32 in each group. The control group took mosapride citrate tablets orally, the TCM enema group added TCM enema on the basis of the control group, and the combined group added acupuncture Zusanli (ST 36)on the basis of the TCM enema group. All three groups were treated continuously for 4 weeks. The main syndromes were scored before and after treatment. The levels of serum gastrin (GAS), motilin (MTL) and somatostatin (SS) were detected by radioimmunoassay. The gastric electrophysiological parameters (waveform response area, waveform frequency and average amplitude) were detected by intelligent dual channel gastrointestinal electrograph, the adverse reactions during treatment were recorded, and the clinical efficacy was evaluated.Results:The total effective rate was 96.9% (31/32) in the combined group, 81.3% (26/32) in the TCM enema group and 68.8% (22/32) in the control group. There was significant difference among the three groups ( χ2=8.72, P=0.013). The scores of abdominal fullness and distention, fatigue, belching acid reflux, dry mouth and bitter mouth in the combined group were significantly lower than those in the TCM enema group and the control group ( F values were 16.39, 13.21, 11.28 and 10.23, respectively, P<0.001). After treatment, the levels of GAS [(140.62±15.19) ng/L vs. (128.79±14.34) ng/L, (115.98±12.40) ng/L, F=21.09], MTL [(268.66±28.21) ng/L vs. (245.89±25.24) ng/L, (230.78±22.43) ng/L, F=30.29] and SS [(70.58±8.17) ng/L vs. (65.50±7.76) ng/L, (59.73±7.05) ng/L, F=33.19] in the combined group were significantly higher than those in the TCM enema group and the control group ( P<0.01). The waveform response area [(172.62±17.14) μV/s vs. (158.56± 15.32) μV/s, (145.48±14.13) μV/s, F=20.24], waveform frequency [(3.86±0.61) cpm vs. (3.29±0.50) cpm, (3.01±0.63) cpm, F=13.17] and average amplitude [(86.51±8.98) μV vs. (75.70±7.93) μV, (68.65±7.46) μV, F=28.11] were significantly higher than those in TCM enema group and control group ( P<0.01). During the treatment period, the incidence of adverse reactions was 18.8% (6/32) in the combined group, 15.6% (5/32) in the TCM enema group and 12.5% (4/32) in the control group. There was no significant difference between the three groups ( χ2=0.47, P=0.789). Conclusion:Acupuncture at Zusanli (ST 36) combined with TCM enema can improve the TCM syndrome scores, gastrointestinal hormone level and gastric electrophysiological parameters of patients with gastroparesis syndrome after gastrointestinal tumor operation, improve the curative effect with safety.
ABSTRACT
[Objective] To investigate the synergistic action of fuming-washing therapy with Qingbixifang ( a herbal lotion mainly composed of Herba Siegesbeckiae, Cortex Phellodendri, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Stephaniae Tetrandrae, Rhizoma Atractylodis, Herba Ecliptae, Nidus Vespae, Olibanum, Myrrha, etc.) on rheumatoid arthritis (RA) with heat retention. [Methods] Sixty patients of RA with heat retention were randomized into groups A and B. Group A ( n = 30) was treated by fuming and washing the affected part with Qingbixifang, and taking Tongbiling Tablets and nimesulide; group B (n = 30) was treated by taking Tongbiling Tablets and nimesulide only. The treatment course of the two groups lasted one month. The time of morning stiffness, grip strength, the number of joints with tenderness, tenderness index, resting pain in joints, the number of swelling joints, swelling index, evaluation by patients themselves and by the doctor were compared before and after treatment. Laboratory parameters such as blood rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC) count and platelet (PLT) count were also observed before and after treatment. [Results] The total effective rate was 90.0% in group A and 66.7% in group B, the difference being significant (P